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Famous Road Trips

Get your kicks on Route 66—or of the other can’t-miss driving routes that crisscross Mississippi River Country. Travel through Illinois and Missouri to visit iconic attractions along America’s most famous drive or steer your vehicle along the Natchez Trace, a historical route that travels from southern Mississippi to Nashville.

Route 66 in Pontiac, Illinois (Credit: Adam Alexander / Illinois Office of Tourism)
Pontiac on Route 66

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